Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with human dissemination.

We observed a stronger effect for Erps (β 1 = 0.087 +/- 0.053, logistic regression, Fig 7E ) with a trend toward significance (p = 0.1).

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>>is there another option? Only one of the two genes has any variation Page: 26 matrix components, >>binds plasminogen as well The statistically-significant relationship between lipoprotein number and probability of dissemination and the borderline significant relationships for copy number of Erps and Mlps (Figure S7D-E) suggest that varying the amount and diversity of linked clusters of surface lipoproteins—which, individually or in combination, may promote survival in the presence of immune defenses, binding to mammalian host tissues and other pathogenic mechanisms— may be a general mechanism for strain specific virulence of Bbss. >>This is a tough hypothesis to follow bc it suggests that strains that have fewer lipoproteins have a lower probability of infecting ANY vertebrate host.

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