The first is that it might be significant in terms of how the disease is treated clinically; a typical example of this is with nephrotic syndromes, where the identification of structural variants in genes related to podocytes provides evidence against immunosuppressive treatments that would otherwise be regularly administered over a period of several months [ 20 ].
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The Role of Genetic Testing in Pediatric Renal Diseases: Diagnostic, Prognostic, and Social Implications.
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