This overrepresentation is both highly significant (HGT score equal to 268 corresponding to a p-value after hypergeometric test equal to 10 −268 , see Methods for a definition of HGT score) and specific to position 2 (aspecificity score of 0%, see Methods ).
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Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import.
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