Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load.

Another point is that the 95% credible interval for cohort 2 seems to indicate a decreasing trend near the end – week 8 post treatment - (Fig. 1D), which corresponds to an increasing CD8+ T cells (Fig. 1E).

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