Concordance between cancer gene alterations in tumor and circulating tumor DNA correlates with poor survival in a real-world precision-medicine population.

Mol Oncol · 2023 · PMC10483598 · PMID 36694946

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

marginal significanceP =0.059so close (0.05 < p ≤ 0.1)

Omitting the time between tests factor resulted in marginal significance of mutual mutations status (HR=1.43, P =0.059).

also in 3,086 other papers

marginally significantP =0.06so close (0.05 < p ≤ 0.1)

However, in the multivariable analysis tumor gene number was not significant and ctDNA gene number was marginally significant (HR=1.08, P =0.06).

also in 14,984 other papers

highly significantno p-value reported

However, a threshold of two or more mutual gene alterations in tissue and blood was highly significant in predicting a worse survival outcome.

also in 82,236 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.