The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization.

For larger consortia summary statistics with sample overlap to the second dataset used, the direction and extent of bias are unknown, but in very large alliances, the bias of weak tools may not be significant, but in medium-sized alliances, potential biases and exaggerated Type 1 error rates should be investigated ( 62 ).

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