highly significantP < 0.001
Significance was defined as follows: ∗ P < 0.05 and # P < 0.05 statistically significant; ∗∗ P < 0.01 and ## P < 0.01 highly significant; ∗∗∗ P < 0.001 and ### P < 0.001 very highly significant. 3.
Significance was defined as follows: ∗ P < 0.05 and # P < 0.05 statistically significant; ∗∗ P < 0.01 and ## P < 0.01 highly significant; ∗∗∗ P < 0.001 and ### P < 0.001 very highly significant. 3.