There are also studies in the clinic showing that it is useful in predicting mortality in sepsis, disseminated intravascular coagulopathy, and bacteriemia.[ 11 , 12 ] There are studies that DNI is a predictive marker that can be used to differentiate the perforated appendix from the non-perforated appendix in adults,[ 13 ] elderly,[ 14 ] and children.[ 15 ] It was found that a DNI value >0.6% was associated with complicated appendicitis in the study conducted by Shin et al.[ 13 ] The cut-off value of above 0.55% for DNI may be significant in the differentiation of complicated and non-complicated appendicitis similar to the literature even though the discriminative ability was found to be poor.
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