Barely Significant
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State-to-State Variation in Opioid Dispensing Changes Following the Release of the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain.

JAMA Netw Open · 2023 · PMC10495870 · PMID 37695587

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a decreasing trendno p-value reported
Level changes (ie, shifts in the model intercept following the 2016 CDC Guideline release) correspond to an immediate shift in each outcome following the 2016 CDC Guideline release, and slope changes correspond to a change in the rate of change (eg, acceleration of a decreasing trend).

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