Pleiotropic influence of DNA methylation QTLs on physiological and ageing traits.

However, the CpG-to-mRNA correlation between them was relatively modest, and although CREBBP formed the central node in the PPI network, the expression of Crebbp was uncorrelated with its cognate CpG, and instead, the Crebbp transcript had a modestly significant inverse correlation with the Hnf1a CpG ( Figure 5f ).

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