Extensive rewiring of the gene regulatory interactions between in vitro-produced conceptuses and endometrium during attachment.

Gene ontology enrichment analysis of genes with greater transcript abundance on day 18 CAR ( N = 805) or ICAR ( N = 583) regions of the endometrium showed an overlap of highly significant (FWER < 0.01; Fig. 2 D and Data Sets S8 and S9 ) categories: “defense response to virus,” “negative regulation of viral genome replication,” “sterol biosynthetic process,” “innate immune response,” “establishment of skin barrier,” and “cholesterol biosynthetic process.” Enrichment of the category “transmembrane transport” was highly significant in ICAR and had a strong tendency in CAR areas of the endometrium (FWER < 0.01; Fig. 2 D and Data Sets S8 and S9 ).

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