Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund's adjuvant-induced paw inflammation model.

In fact, the blue curve representing the edema kinetics of the aP2-ALOX15 mice, was consistently below the green curve recorded for wildtype mice and statistical evaluation of the experimental raw data indicated a borderline significant difference ( p = 0.0808, see Fig. 3 ).

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In fact, the green bodyweight curve (wildtype mice) was consistently above the blue curve (aP2- ALOX15 mice) and statistical evaluation (two-way repeated measure ANOVA) of the two curves suggested a borderline significance ( p = 0.1130).

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