Mouse models of <i>SYNGAP1</i>-related intellectual disability.

Proc Natl Acad Sci U S A · 2023 · PMC10500186 · PMID 37669379

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Our RNA-seq data revealed highly significant changes in several genes associated with synaptic plasticity, intrinsic excitability, transcription factors, and NDD including Stim2 , Elk1, Aes ( Tle5 ), Mrm1 , Sec63, Wwox , and Camk4 , suggesting widespread transcriptional changes that may contribute to or counteract the phenotypic features of SRID.

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