Retrospective cohort study investigating synergism of air pollution and corticosteroid exposure in promoting cardiovascular and thromboembolic events in older adults.

BMJ Open · 2023 · PMC10503335 · PMID 37709308

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Evaluating the interactions between PM 2.5 and corticosteroid use on the additive scale, we observed significant interactions (RERI (95% CI)) associated with increasing PM 2.5 from 8 μg/m 3 to 12 μg/m 3 for HF (15.6% (4.0%, 27.3%)), with a borderline significance interaction detected for death (12.5 (−0.6%, 25.5%)).

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