Identification of combinatorial miRNA panels derived from extracellular vesicles as biomarkers for esophageal squamous cell carcinoma.

2.3 The biological role of candidate miRNAs In another, Pearson's correlation analysis was performed to examine the correlation of four candidate miRNAs derived from plasma and plasma EVs, and the result showed that miR‐636 derived from EVs showed a significant negative correlation with miR‐7641, consistent with the qRT‐PCR validation results; however, there was no significant correlation between the level from plasma EVs‐derived miRNAs and plasma‐derived miRNAs, indicating that there might be significant differences in the expression and diagnostic efficacy of plasma miRNAs versus plasma EVs‐derived miRNAs for disease (Figure S3C ).

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