Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau.

Surprisingly, in neurons treated for 3 days, the CDI D/N ratios of cell tau showed a highly significant correlation (p = 0.003) with the D/N ratios of AD-tau brain inocula, with some intra-individual range (Fig. 5 C).

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These observations were confirmed with neuronal lysates where total levels of pre-synaptic markers Bassoon and synaptophysin were not significantly affected in contrast to the levels of post-synaptic markers PSD95 and Homer showing a decreasing trend.

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