Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.

A highly significant fit was observed for the logistic transform of the COV-ranked sub- meta -analyses (r 2 = 0.95, p <.00001, inflection point at COV = 19%, Table 2 ), with larger choline effect sizes in studies with COV ≤ 19% ( Fig. 8 ).

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