Acute HDM exposure shows time-of-day and sex-based differences in the severity of lung inflammation and circadian clock disruption.

J Allergy Clin Immunol Glob · 2023 · PMC10509939 · PMID 37781650

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an increasing trendno p-value reported

Acute HDM-exposed female mice showed a significant increase in rEOSs at ZT0 and ZT12, an increasing trend of IMs at ZT0 and ZT12, and a significant reduction in AMs at ZT0 in lung tissues compared with their respective PBS groups ( Fig 2 ).

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a decreasing trendno p-value reported

However, male mice showed a decreasing trend at ZT12 compared with ZT0 in PBS- and HDM-exposed groups ( Fig 2 ).

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