Identification of single nucleotide polymorphisms (SNPs) associated with chronic graft-versus-host disease in patients undergoing allogeneic hematopoietic cell transplantation.

Support Care Cancer · 2023 · PMC10511391 · PMID 37731134

Europe PMC DOI

hedged sentences

0.0525

closest p · 1.0× alpha

0.0525

boldest claim

The sentences

marginal significancep = 0.0525so close (0.05 < p ≤ 0.1)

However, CADD scores of two candidate SNPs (rs10975820 [ KANK1 : R130C19.3 ] and rs4465021 [ KDM4C ]) not identified as lead SNPs, exceeded this threshold (Table 2 ). The Fisher’s exact tests of the lead SNPs comparing the proportions of heterozygous and homozygous alternate genotypes resulted in three of the four lead SNPs being significant ( p < 0.05) and one having a marginal significance ( p = 0.0525) (Table 3 and Online Resource 4 ).

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marginally significantp = 0.0525so close (0.05 < p ≤ 0.1)

Using the Fisher’s Exact test, these proportions were determined as marginally significant ( p = 0.0525).

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