Genome-Wide Association for Itraconazole Sensitivity in Non-resistant Clinical Isolates of <i>Aspergillus fumigatus</i>.

Validation of a GWA Candidate Gene via CRISPR/Cas9 Gene Deletion We chose to functionally examine the role of Afu2g02220 because (i) the SNP located in this gene had highly significant p -values in both GWA analyses (ii) Afu2g02220 has a predicted functional role in sterol metabolism, and ITCZ targets the ergosterol biosynthesis pathway and (iii) Afu2g02220 was up-regulated during ITCZ exposure ( Supplementary Figure 5 ).

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