Sézary syndrome originates from heavily mutated hematopoietic progenitors.

As shown in Figure 6 A, we observed only an increasing trend in IL-4 cytokine production when CD26 − Sézary cells were incubated with autologous APCs pulsed with lysates from cultured (major histocompatibility complex-II + ) keratinocytes, but not human skin lysates, in independent experiments in 2 of 3 patients.

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