Fine-grained age-matching improves atrophy-based detection of mild cognitive impairment more than amyloid-negative reference subjects.

The most remarkable difference was observed for parietal GM at a Z-threshold of −4.5, but this difference was barely significant (AUC amyloid-negative CN reference group = 0.689, AUC amyloid-negative and –positive reference group = 0.593, DeLong’s Test p = 0.039).

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