To account for a slight trend towards fewer lesions in SLC25A51 knockdown cells even directly following H 2 O 2 treatment, lesions after 2 and 4 h recovery were normalized to the first timepoint, H 2 O 2 treatment without recovery.
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Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels.
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