Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer.

Nat Commun · 2023 · PMC10517947 · PMID 37741832

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highly significantno p-value reported

Among these, a missense variant in the core autophagy gene ATG16L1 (T300A), that regulates its caspase-mediated degradation, is established as a highly significant risk allele for Crohn’s disease (CD) 10 – 13 as well as a putative prognostic factor in CRC 14 and gastric cancer 15 .

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