Synovium is a sensitive tissue for mapping the negative effects of systemic iron overload in osteoarthritis: identification and validation of two potential targets.

We also observed an increasing trend of ferritin and Fe 2+ levels in the synovium with the progression of K–L grade (Fig. 8 C, * P < 0.05, ** P < 0.01, *** P < 0.001 versus K–L Grade 2; # P < 0.05, ### P < 0.001 versus K–L Grade 3).

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