Role of biochemical markers and autoantibodies in diagnosis of early-stage primary biliary cholangitis.

Comparison of biochemical and immunological indicators among the three groups The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were normal or mildly increased in the early-stage PBC patients, and an increasing trend with the progression of the pathological stage was observed.

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With pathological progression, a decreasing trend for albumin and albumin/globulin levels was observed, and there were statistically significant differences among the three groups and between the early stage group and stage IV group ( P = 0.005 and 0.001, respectively).

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