B cells play a crucial role by producing antibodies and facilitating the humoral immune response, rendering them highly significant in establishing protective immunity against SARS-CoV-2 ( 122 ), in addition T cells differentiate into cytotoxic T lymphocytes (CD8+) and helper T-cells (CD4+) engaging with the COVID-19 infection through distinct interactions ( 123 ).
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Rationale for combined therapies in severe-to-critical COVID-19 patients.
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