Functional characterization of a single nucleotide polymorphism associated with Alzheimer's disease in a hiPSC-based neuron model.

PLoS One · 2023 · PMC10521995 · PMID 37751459

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highly significantp = 8.9e-34actually significant

This analysis revealed a novel variant, rs148726219, located on chromosome 19q13.32 (>500 kb from APOE ) which showed highly significant association with AD in DF3 (p = 8.9e-34, OR = 2.5) and had further increased significance in the later release DF6 (p = 2.7e-54).

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