MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females.

Exposure to these factors increases the probability of thyroid dysfunction; this may explain the inability of the current study to find a highly significant association between MTHFR polymorphisms and thyroid disease in this sample of patients.

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No reliable valid method was developed to assess patients’ dietary intake of folate; this may be significant, as flour in Jordan is fortified with iron and folic acid under the auspices of the Ministry of Health and the vast majority of Jordanians eat bread daily (Food Fortification Initiative, 2014) ( 44 ).

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