Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals.

Positive hits based on a single read may be significant and should be investigated, depending on the coverage level and other criteria. • Could NGS be used in combination with a previous step of cell culture for enrichment? o Blandine de Saint-Vis indicated that it could be done but it would require a cell sensitive to all viruses and monoclonal antibodies to neutralize the virus from the vaccine, so this is a challenge.

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