extremely significantP < 0.0001
P values are calculated using unpaired t tests with Welch’s correction, and the levels of statistical significance are assigned as follows: P ≥ 0.05, not significant (n.s.); 0.01 ≤ P < 0.05, significant (*); 0.001≤ P < 0.01, very significant (**); P 0.0001 ≤ P < 0.001, extremely significant (***); P < 0.0001, extremely significant (****).