At more advanced stages of aging, there are highly significant changes to the cellular composition of the skeletal muscle, with inter- and intra-myofiber infiltration of fat and low-level inflammation possibly driven by intramuscular degenerative processes and an accumulation of senescent cells and the impact of their secretome ([ 33 , 58 , 59 ]).
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Emergence and Progression of Behavioral Motor Deficits and Skeletal Muscle Atrophy across the Adult Lifespan of the Rat.
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