Safety and Metabolic Tolerance of Citrate Anticoagulation in Critically Ill Polytrauma Patients with Acute Kidney Injury Requiring an Early Continuous Kidney Replacement Therapy.

When the patients of the group Citrate were at risk of citrate accumulation (lactate levels > 6 mmol/L and/or with an increasing trend) [ 11 , 12 ], they started CKRT without an anticoagulant or with heparin at 125 U/h, and within 12 h, they shifted to citrate anticoagulation at a circuit citratemia of 2 mmol/L. 2.6.

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