Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on <i>FMR1</i> Premutation.

After 6 months of treatment, no significant motor improvements were noted; however, improvements were seen on measures of visual working memory and borderline significant improvement was seen on the Montreal Cognitive Assessment (MoCA).

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Although this finding did not quite reach statistical significance, it suggested that carriers with an average or greater IQ (who later turned out to have the PM) had an increased prevalence of early menopause [ 2 ].

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A strong argument for the association between the PM status and psychological/psychiatric problems in female carriers was provided by the finding of highly significant (nonlinear) negative correlations between the size of CGG repeats and a great majority of SCL-90-R subscale scores and all the global indices [ 74 ].

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