Effects of Early Exposure to Isoflurane on Susceptibility to Chronic Pain Are Mediated by Increased Neural Activity Due to Actions of the Mammalian Target of the Rapamycin Pathway.

Although previous acute or sub-acute (<14 days) studies showed that SNI elevates neuronal activity and mTOR protein level in pain circuitry [ 26 , 48 , 60 , 66 ], in our chronic experiments (8 weeks after injury), the effect of SNI on cellular and molecular alteration became almost not significant.

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