Continuous Manufacturing of Solvent-Free Cyclodextrin Inclusion Complexes for Enhanced Drug Solubility via Hot-Melt Extrusion: A Quality by Design Approach.

Pharmaceutics · 2023 · PMC10536280 · PMID 37765172

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a positive trendno p-value reported

Effect of Independent Factors on Saturation Solubility According to the solubility equation, a positive trend in solubility was observed with a high polymer concentration, low processing temperature, and high screw speed.

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