Genetic association of beta-lactams-induced hypersensitivity reactions: A systematic review of genome-wide evidence and meta-analysis of candidate genes.

75 The first published GWAS of BL-allergy with relatively small participants and inadequate statistical power, thus provided a marginal significance of associations of HLA regions. 61 Later, with tremendously large study cohorts, Krebs et al and Nicoletti et al revealed promising associations in which polymorphisms of HLA-B ∗55:01 and HLA-DRB1 ∗10:01 were addressed.

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