Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease.

Notably, the proportion of the memory B subset decreased significantly in patients with IgG4-RD compared with HCs, while plasmablasts and dividing plasmablasts showed an increasing trend ( Figure 2, B and C , and Supplemental Figure 2D ), suggesting a possible transition from memory B to antibody-secreting plasmablasts in IgG4-RD.

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We further examined the proportions of 3 MN subsets in a larger population and found CMs had an increasing trend, while NCMs had a decreasing trend in IgG4-RD patients compared with HCs ( Figure 5C and Supplemental Figure 5B ).

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