Progressive tauopathy disrupts breathing stability and chemoreflexes during presumptive sleep in mice.

During presumptive sleep, there was a marginally significant interaction of genotype and age on Type I post-sigh apnea frequency (F 2,64 = 3.113, p = 0.050, 2-way mixed effects ANOVA), driven by a significantly higher sigh frequency in aged rTg4510 mice (1.1 ± 0.3 apneas/min) vs . young (0.6 ± 0.2; p = 0.019) and age-matched nTg controls (0.1 ± 0.1; p < 0.001; Figure 4E ).

also in 26,082 other papers