Subsequently, employing the same panel of 28 genes, the same cohort of PDAC patients and the same experimental approaches, these authors only found highly significant differences in the mean number of hypermethylated genes at stage IV, but not at stages I, II or III, suggesting an accumulation of hypermethylated promoter regions during cancer development and progression [ 76 ].
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Diagnosing and monitoring pancreatic cancer through cell-free DNA methylation: progress and prospects.
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