Given that the TCR zeta TM already had a charge in the TM domain (as do all TCR sTM domains) does this make the TCR more or less challenging to engineer in this way? Given that the charges in the TM domain of the TCR are highly significant for their function, does this make the addition of extra charges problematic if the intention is for them to insert into the complex? 2.
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Allosteric inhibition of the T cell receptor by a designed membrane ligand.
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