Moreover, as COL II, aggrecan and SOX9 are highly significant anabolic enzymes with crucial roles in maintaining extracellular matrix (ECM) cartilage homeostasis, the expression of these proteins was determined to analyse the anabolism level in chondrocytes.
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Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3.
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