Lung mechanics showing sex-based differences and circadian time-of-day response to bleomycin-induced lung injury in mice.

Overall, most of the alterations in lung mechanics that were highly significant in BLM‐challenged mice versus sham were observed at ZT0. 3.5 Pressure–Volume ( PV ) loop measurements Pressure–Volume (PV) loop measurements showed a characteristic downward shift in the curve 14 days post‐BLM challenge in both females and males, suggesting increased lung stiffness (Figure 3a and Figure S3a,b ).

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Similarly, lung tissue‐specific changes H and G were significantly increased in BLM‐challenged mice versus sham at ZT0 and ZT12 with the exception that R n significantly reduced in the BLM group at ZT12 but showed an increasing trend at ZT0 (Figure S2b ).

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