Although EBV also failed to achieve significance, it is regarded as a promising biomarker for ICI treatment, considering its association with PD‐L1 overexpression and immune cell signaling. 8 In addition, the prevalence of PIK3CA mutations in EBV‐positive GCs may support dual targeting of PIK3CA mutations and PD‐1 inhibition.
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Impact of programmed death-ligand 1 (PD-L1) positivity on clinical and molecular features of patients with metastatic gastric cancer.
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