Integration of metabolomics and machine learning revealed tryptophan metabolites are sensitive biomarkers of pemetrexed efficacy in non-small cell lung cancer.

Twenty‐five metabolites with a decreasing trend in the ND group compared with the H group, an increasing trend in the S group compared with the ND group, a decreasing trend in the R group compared with S group (Figure 5A ), or 37 metabolites with opposite directions were shown in the Venn plot (Figure 5B ). 3.4 Pathway analysis of differential metabolites The selected most important metabolites in serum among each group were further analyzed by the online tool MetaboAnalyst 5.0 ( https://www.metaboanalyst.ca ) to reveal the key pathways changed after pemetrexed treatment.

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