Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery.

The differences between CASK -mutant and control neurite arbors were highly significant statistically, with magnitudes suggestive of biological significance: total neurite length (-35%; p = 0.0008), territory area (-48%; p = 0.0004), higher-order branch number (-30%; p = 0.0023) and branch density (+ 39%; p = 0.0006).

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