Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study.

1 A, B, genetically predicted serum iron was significantly associated with genetic predisposition to GrimAge acceleration (GrimAA, Beta IVW = 0.27 years per standard deviation (SD) increase in serum iron, P = 8.54E−03 in 2014 datasets; Beta IVW = 0.31, P = 1.25E−02 in 2021 datasets), HannumAge acceleration (HannumAA, Beta IVW = 0.32, P = 4.50E−03 in 2014 datasets; Beta IVW = 0.32, P = 8.03E−03 in 2021 datasets) and intrinsic epigenetic age acceleration (IEAA, Beta IVW = 0.34, P = 5.33E−04 in 2014 datasets; Beta IVW = 0.49, P = 9.94E−04 in 2021 datasets), but partially significant in PhenoAge acceleration (PhenoAA, Beta IVW = 0.47, P = 2.54E−02 in 2014 datasets; Beta IVW = 0.30, P = 1.28E−01 in 2021 datasets).

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