Engineering NK-CAR.19 cells with the IL-15/IL-15Rα complex improved proliferation and anti-tumor effect <i>in vivo</i>.

Front Immunol · 2023 · PMC10561086 · PMID 37818365

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highly significantno p-value reported

These analyses indicated that the most highly significant pathways and functions underlying the NK-92-CAR-IL15/IL-15Rα higher potency relative to the other NK-CAR include (top 3 per database queried), IFNα/β signaling , Cell-cell junction, Glycolysis, Immune system , RANKL regulation of apoptosis and immune response , PI3K/AKT/mTOR signaling , Immune response to tuberculosis , Interferon Gamma response , and Apoptosis .

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