MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.

Pearson correlation analysis indicated a positive and highly significant correlation between TDO2 and CYP19A1 ( R = 0.78, P = 5.96 × 10 –5 ), TGFb3 ( R = 0.88, P = 3.3 × 10 –7 ), HOXA13 ( R = 0.62, P = 0.003), COL1A1 ( R = 0.65, P = 0.002), COL1A2 ( R = 0.60, P = 0.005), COL3A1 ( R = 0.79, P = 3.95 × 10 –5 ), CCND1 ( R = 0.65, P = 0.002), IGF2 ( R = 0.79, P = 3.48 × 10 –5 ), and WNT4 ( R = 0.56, P = 0.011) ( Figure 8 ).

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