Lack of thyroid hormone receptor beta is not detrimental for non-alcoholic steatohepatitis progression.

Most remarkably, at thermoneutrality, the endogenously 2- to 3-fold elevated 3,3′,5-triiodothyronine (T3) and thyroxine (T4) levels of TRβ knockout mice 22 , 23 were almost normalized: Only a mild increase remained in total T4 at 8 weeks and 16 weeks (difference between wild-type and TRβ knockout 26% at 8 weeks and 38% at 16 weeks, average of both diets), which however failed to reach significance in post hoc tests with the exception of the 16 weeks CD-HFD animals.

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